Indianist sumak kawsay, an alternative to global capitalism

The indianist sumak kawsay had a special political and intellectual relevance in Ecuador (and Bolivia) in the first decade of the twenty-first century. Since then, the influence of its approaches —and those of the different branches of good living— has grown and formed synergies with other heterodox trends such as degrowth, feminist economics and deep ecology, among others. The global pandemic of COVID-19 has highlighted the incompatibility of the capitalist system and the paradigms that sustain it with the life of the planet and of people. This article reflects on the proposals that are emerging around the construction of a global sumak kawsay as an alternative to development and capitalism, showing the potentialities and weaknesses of this philosophy, worldview and way of life from a postmodern perspective. © 2023 Universitat Jaume I. All rights reserved.

COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era.

BACKGROUND: Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. MATERIAL AND METHODS: We included patients with moderate/severe IEI aged 0-21 years old: cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used: nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins. RESULTS: Seven from sixty-five patients tested positive (prevalence: 10.7% (7%-13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course. CONCLUSIONS: In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI.

The CoronaSurveys System for COVID-19 Incidence Data Collection and Processing

CoronaSurveys is an ongoing interdisciplinary project developing a system to infer the incidence of COVID-19 around the world using anonymous open surveys. The surveys have been translated into 60 languages and are continuously collecting participant responses from any country in the world. The responses collected are pre-processed, organized, and stored in a version-controlled repository, which is publicly available to the scientific community. In addition, the CoronaSurveys team has devised several estimates computed on the basis of survey responses and other data, and makes them available on the project's website in the form of tables, as well as interactive plots and maps. In this paper, we describe the computational system developed for the CoronaSurveys project. The system includes multiple components and processes, including the web survey, the mobile apps, the cleaning and aggregation process of the survey responses, the process of storage and publication of the data, the processing of the data and the computation of estimates, and the visualization of the results. In this paper we describe the system architecture and the major challenges we faced in designing and deploying it.

Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels.

AIM: An increased risk of venous thromboembolism (VTE) in patients with COVID-19 pneumonia admitted to intensive care unit (ICU) has been reported. Whether COVID-19 increases the risk of VTE in non-ICU wards remains unknown. We aimed to evaluate the burden of asymptomatic deep vein thrombosis (DVT) in COVID-19 patients with elevated D-dimer levels. METHOD: In this prospective study consecutive patients hospitalized in non-intensive care units with diagnosis of COVID-19 pneumonia and D-dimer > 1000 ng/ml were screened for asymptomatic DVT with complete compression doppler ultrasound (CCUS). The study was approved by the Institutional Ethics Committee. RESULTS: The study comprised 156 patients (65.4% male). All but three patients received standard doses of thromboprophylaxis. Median days of hospitalization until CCUS was 9 (IQR 5-17). CCUS was positive for DVT in 23 patients (14.7%), of whom only one was proximal DVT. Seven patients (4.5%) had bilateral distal DVT. Patients with DVT had higher median D-dimer levels: 4527 (IQR 1925-9144) ng/ml vs 2050 (IQR 1428-3235) ng/ml; p < 0.001. D-dimer levels > 1570 ng/ml were associated with asymptomatic DVT (OR 9.1; CI 95% 1.1-70.1). D-dimer showed an acceptable discriminative capacity (area under the ROC curve 0.72, 95% CI 0.61-0.84). CONCLUSION: In patients admitted with COVID-19 pneumonia and elevated D-dimer levels, the incidence of asymptomatic DVT is similar to that described in other series. Higher cut-off levels for D-dimer might be necessary for the diagnosis of DVT in COVID-19 patients.